Deleting CBCAS genes opens the door to another problem, namely that this genetic cluster also houses certain pathogen response genes. The researchers hypothesized that “[b]reeding for less than 0.3% THCA production may enrich for pathogen susceptibility and higher patient fungal exposure.” In other words, selective breeding for low-THC hemp may weaken its pathogen resistance.

Source: https://terpenesandtesting.com/sequencing-cannabis-genomes